Cerebral artery myogenic reactivity: The next frontier in developing effective interventions for subarachnoid hemorrhage.

ABSTRACT: Aneurysmal subarachnoid hemorrhage (SAH) is a devastating cerebral event that kills or debilitates the majority of those afflicted. The blood that spills into the subarachnoid space stimulates profound cerebral artery vasoconstriction and consequently, cerebral ischemia. Thus, once the initial bleeding in SAH is appropriately managed, the clinical focus shifts to maintaining/improving cerebral perfusion. However, current therapeutic interventions largely fail to improve clinical outcome, because they do not effectively restore normal cerebral artery function. This review discusses emerging evidence that perturbed cerebrovascular "myogenic reactivity," a crucial microvascular process that potently dictates cerebral perfusion, is the critical element underlying cerebral ischemia in SAH. In f

SUBMITTER: Lidington D 

PROVIDER: S-EPMC5757446 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature