Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts.

ABSTRACT: Skin has gained substantial attention as a vaccine target organ due to its immunological properties, which include a high density of professional antigen presenting cells (APCs). Previous studies have demonstrated the effectiveness of this vaccination route not only in animal models but also in adults. Young children represent a population group that is at high risk from influenza infection. As a result, this group could benefit significantly from influenza vaccine delivery approaches through the skin and the improved immune response it can induce. In this study, we compared the immune responses in young BALB/c mice upon skin delivery of influenza vaccine with vaccination by the conventional intramuscular route. Young mice that received 5 μg of H1N1 A/Ca/07/09 influenza subunit vaccine usi

SUBMITTER: Koutsonanos DG 

PROVIDER: S-EPMC5757502 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature