Longitudinal effects of cognitive behavioral therapy for depression on the neural correlates of emotion regulation.

ABSTRACT: Cognitive behavioral therapy (CBT) is effective for a substantial minority of patients suffering from major depressive disorder (MDD), but its mechanism of action at the neural level is not known. As core techniques of CBT seek to enhance emotion regulation, we scanned 31 MDD participants prior to 14 sessions of CBT using functional magnetic resonance imaging (fMRI) and a task in which participants engaged in a voluntary emotion regulation strategy while recalling negative autobiographical memories. Eighteen healthy controls were also scanned. Twenty-three MDD participants completed post-treatment fMRI scanning, and 12 healthy volunteers completed repeat scanning without intervention. Better treatment outcome was associated with longitudinal enhancement of the emotion regulation-dependent

SUBMITTER: Rubin-Falcone H 

PROVIDER: S-EPMC5757508 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature