Hemophagocytic Lymphohistiocytosis in Adults with Intraocular Involvement: Clinicopathologic Features of 3 Cases.

ABSTRACT:

Background/aims

Hemophagocytic lymphohistiocytosis (HLH) is an infrequent inflammatory multisystemic syndrome. Only rare cases with ophthalmic involvement describing their pathologic features have been previously reported.

Methods

We report 3 cases of adult-onset HLH with bilateral ocular involvement and describe their clinicopathologic features.

Results

Three adult males - 2 with a history of viral infection - developed persistent fever, fatigue, bone marrow abnormalities, and irreversible multiorgan failure. Visual impairment was also documented in 2 cases. Complete autopsies were performed. Ophthalmic pathology demonstrated a bilateral histiocytic infiltrate with scant lymphocytes affecting the uvea. Focal extension to the retina, optic nerve, and trabecular meshwo

SUBMITTER: Vizcaino MA 

PROVIDER: S-EPMC5757609 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature