ShinyGPA: An interactive visualization toolkit for investigating pleiotropic architecture using GWAS datasets.

ABSTRACT: In spite of accumulating evidence suggesting that different complex traits share a common risk basis, namely pleiotropy, effective investigation of pleiotropic architecture still remains challenging. In order to address this challenge, we developed ShinyGPA, an interactive and dynamic visualization toolkit to investigate pleiotropic structure. ShinyGPA requires only the summary statistics from genome-wide association studies (GWAS), which reduces the burden on researchers using this tool. ShinyGPA allows users to effectively investigate genetic relationships among phenotypes using a flexible low-dimensional visualization and an intuitive user interface. In addition, ShinyGPA provides joint association mapping functionality that can facilitate biological understanding of the pleiotropic arc

SUBMITTER: Kortemeier E 

PROVIDER: S-EPMC5757942 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature