New 1,1'-Ferrocene Bis(sulfonyl) Reagents.

ABSTRACT: Several new 1,1'-bis(sulfonyl)ferrocenes designed for the synthesis of sulfonamide linked biological conjugates have been prepared. 1,1'-Bis(sulfonylbromide)ferrocene can be produced from the corresponding sulfonylchloride via a bis(sulfonylhydrazide) intermediate. Bis(sulfonyl-N-hydroxybenzotriazole)ferrocene can also be synthesized from the sulfonyl chloride, and reaction of glycine methyl ester with the sulfonyl chloride affords a [3]ferrocenophane complex. All new compounds have been structurally characterized by X-ray crystallography.

SUBMITTER: Chanawanno K 

PROVIDER: S-EPMC5758046 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature