Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing.

ABSTRACT: Action potentials clustered into high-frequency bursts play distinct roles in neural computations. However, little is known about ionic currents that control the duration and probability of these bursts. We found that, in cartwheel inhibitory interneurons of the dorsal cochlear nucleus, the likelihood of bursts and the interval between their spikelets were controlled by Ca²⁺ acting across two nanodomains, one between plasma membrane P/Q Ca²⁺ channels and endoplasmic reticulum (ER) ryanodine receptors and another between ryanodine receptors and large-conductance, voltage- and Ca²⁺-activated K⁺ (BK) channels. Each spike triggered Ca²⁺-induced Ca²⁺ release (CICR) from the ER immediately beneath somatic, but not axonal or dendri

SUBMITTER: Irie T 

PROVIDER: S-EPMC5758055 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature