Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome.

ABSTRACT: Healthy pregnancy depends on proper placentation-including proliferation, differentiation, and invasion of trophoblast cells-which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of Inverted formin 2 (INF2) alters intracellular trafficking and significantly impairs invasion in a model of human extravillous trophoblasts. Furthermore, global loss of Inf2 in mice recapitulates maternal and fetal phenotypes of placental insufficiency. Inf2^-/- dams have reduced spiral artery numbers and late gestational hypertension with resolution following delivery. Inf2^-/- fetuses are growth restricted and de

SUBMITTER: Lamm KYB 

PROVIDER: S-EPMC5758111 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature