Differentiating pulmonary transfusion reactions using recipient and transfusion factors.

ABSTRACT:

Background

It is increasingly recognized that recipient risk factors play a prominent role in possible transfusion-related acute lung injury (pTRALI) and transfusion-associated circulatory overload (TACO). We hypothesized that both transfusion and recipient factors including natriuretic peptides could be used to distinguish TRALI from TACO and pTRALI.

Study design and methods

We performed a post hoc analysis of a case-control study of pulmonary transfusion reactions conducted at the University of California at San Francisco and Mayo Clinic, Rochester. We evaluated clinical data and brain natriuretic peptides (BNP) levels drawn after transfusion in patients with TRALI (n = 21), pTRALI (n = 26), TACO (n = 22), and controls (n = 24). Logistic regression and receiver operating c

SUBMITTER: Roubinian NH 

PROVIDER: S-EPMC5758383 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature