β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

ABSTRACT:

Background and aims

β-Caryophyllene (BCP) is a plant-derived FDA approved food additive with anti-inflammatory properties. Some of its beneficial effects in vivo are reported to involve activation of cannabinoid CB₂ receptors that are predominantly expressed in immune cells. Here, we evaluated the translational potential of BCP using a well-established model of chronic and binge alcohol-induced liver injury.

Methods

In this study, we investigated the effects of BCP on liver injury induced by chronic plus binge alcohol feeding in mice in vivo by using biochemical assays, real-time PCR and histology analyses. Serum and hepatic BCP levels were also determined by GC/MS.

Results

Chronic treatment with BCP alleviated the chronic and binge alcohol-induced liver in

SUBMITTER: Varga ZV 

PROVIDER: S-EPMC5758392 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature