Drug repurposing screens and synergistic drug-combinations for infectious diseases.

ABSTRACT: Infectious diseases account for nearly one fifth of the worldwide death toll every year. The continuous increase of drug-resistant pathogens is a big challenge for treatment of infectious diseases. In addition, outbreaks of infections and new pathogens are potential threats to public health. Lack of effective treatments for drug-resistant bacteria and recent outbreaks of Ebola and Zika viral infections have become a global public health concern. The number of newly approved antibiotics has decreased significantly in the last two decades compared with previous decades. In parallel with this, is an increase in the number of drug-resistant bacteria. For these threats and challenges to be countered, new strategies and technology platforms are critically needed. Drug repurposing has emerged as

SUBMITTER: Zheng W 

PROVIDER: S-EPMC5758396 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature