Effect of immediate initiation of antiretroviral treatment on the risk of acquired HIV drug resistance.

ABSTRACT:

Objective

We estimated and compared the risk of clinically identified acquired drug resistance under immediate initiation [the currently recommended antiretroviral therapy (ART) initiation strategy], initiation with CD4 cell count less than 500 cells/μl and initiation with CD4 cell count less than 350 cells/μl.

Design

Cohort study based on routinely collected data from the HIV-CAUSAL collaboration.

Methods

For each individual, baseline was the earliest time when all eligibility criteria (ART-naive, AIDS free, and others) were met after 1999. Acquired drug resistance was defined using the Stanford classification as resistance to any antiretroviral drug that was clinically identified at least 6 months after ART initiation. We used the parametric g-formula to adjust for

SUBMITTER: Lodi S 

PROVIDER: S-EPMC5758415 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature