Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain.

ABSTRACT: Genes generated by whole genome duplications (WGD) can be co-opted by changing their regulation process or altering their coding proteins, which has been shown contributable to the emergence of vertebrate morphological novelties such as vertebrate cartilage. Mouse khdrbs genes, differing from its invertebrate orthologs, were mainly expressed in brain, hinting that khdrbs gene family as a member of genetic toolkit may be linked to vertebrate brain development. However, the evolutionary relationship between khdrbs gene family and vertebrate brain development is unclear. First, we analyzed the evolutionary history of khdrbs gene family in metazoans, and then investigated their expression patterns during early development and in adulthood of zebrafish. We found that

SUBMITTER: Wang S 

PROVIDER: S-EPMC5758493 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature