Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes.

ABSTRACT: The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional imaging in the adult mouse neocortex, we here reveal that parvalbumin- and somatostatin-expressing interneurons, two key interneuron classes in the brain, differentially signal to astrocytes inducing weak and robust GABA_B receptor-mediated Ca²⁺ elevations, respectively. Furthermore, the astrocyte response depresses upon parvalbumin interneuron repetitive stimulations and potentiates upon somatostatin interneuron repetitive stimulations, revealing a distingui

SUBMITTER: Mariotti L 

PROVIDER: S-EPMC5758790 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature