Associations of Tumor PD-1 Ligands, Immunohistochemical Studies, and Textural Features in ¹⁸F-FDG PET in Squamous Cell Carcinoma of the Head and Neck.

ABSTRACT: To know tumor PD-L1 expression through IHC or the FDG-PET related radiomics, we investigated the association between programmed cell death protein 1 ligand (PD-L1) expression and immunohistochemical (IHC) biomarkers or textural features of 18F-fluoro-2-deoxdeoxyglucose positron emission tomography (¹⁸F-FDG PET) in 53 oropharyngeal or hypopharyngeal cancer patients who were ready to undergo radiotherapy-based treatment. Differences in textural features or biomarkers between tumors with and without PD-L1 expression were tested using a Mann-Whitney U test. The predicted values for PD-L1 expression were examined using logistic regression analysis. The mean percentages of tumor PD-L1 expression were 6.2 ± 13.5. Eighteen tumors had PD-L1 expression ≥5%, whereas 30 tumors ≥1%. Using a

SUBMITTER: Chen RY 

PROVIDER: S-EPMC5758832 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature