Ontology highlight
ABSTRACT:
SUBMITTER: Cucco F
PROVIDER: S-EPMC5758895 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nucleic acids research 20180101 1
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development. Sister chromatid separation is triggered by Separase, an evolutionary conserved protease that cleaves the cohesin complex, allowing the dissolution of sister chromatid cohesion. Here we provide evidence that Separase participates in genomic stability maintenance by controlling replication fork speed. We found that Sepa ...[more]