Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad S
PROVIDER: S-EPMC5758906 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ahmad Shandar S Prathipati Philip P Tripathi Lokesh P LP Chen Yi-An YA Arya Ajay A Murakami Yoichi Y Mizuguchi Kenji K
Nucleic acids research 20180101 1
DNA-binding proteins (DBPs) perform diverse biological functions ranging from transcription to pathogen sensing. Machine learning methods can not only identify DBPs de novo but also provide insights into their DNA-recognition dynamics. However, it remains unclear whether available methods that can accurately predict DNA-binding sites in known DBPs can also identify novel DBPs. Moreover, sequence information is blind to the cellular- and disease-specific contexts of DBP activities, whereas the un ...[more]