Diversity-generating retroelements: natural variation, classification and evolution inferred from a large-scale genomic survey.

ABSTRACT: Diversity-generating retroelements (DGRs) are novel genetic elements that use reverse transcription to generate vast numbers of sequence variants in specific target genes. Here, we present a detailed comparative bioinformatic analysis that depicts the landscape of DGR sequences in nature as represented by data in GenBank. Over 350 unique DGRs are identified, which together form a curated reference set of putatively functional DGRs. We classify target genes, variable repeats and DGR cassette architectures, and identify two new accessory genes. The great variability of target genes implies roles of DGRs in many undiscovered biological processes. There is much evidence for horizontal transfers of DGRs, and we identify lineages of DGRs that appear to have specialized properties. Because GenBan

SUBMITTER: Wu L 

PROVIDER: S-EPMC5758913 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature