Improving adherence to healthy dietary patterns, genetic risk, and long term weight gain: gene-diet interaction analysis in two prospective cohort studies.

ABSTRACT:

Objective

To investigate whether improving adherence to healthy dietary patterns interacts with the genetic predisposition to obesity in relation to long term changes in body mass index and body weight.

Design

Prospective cohort study.

Setting

Health professionals in the United States.

Participants

8828 women from the Nurses' Health Study and 5218 men from the Health Professionals Follow-up Study.

Exposure

Genetic predisposition score was calculated on the basis of 77 variants associated with body mass index. Dietary patterns were assessed by the Alternate Healthy Eating Index 2010 (AHEI-2010), Dietary Approach to Stop Hypertension (DASH), and Alternate Mediterranean Diet (AMED).

Main outcome measures

Five repeated measurements of four year change

SUBMITTER: Wang T 

PROVIDER: S-EPMC5759092 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature