Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.

ABSTRACT:

Importance

It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been established.

Objective

To determine how sex and APOE genotype affect the risks for developing MCI and AD.

Data sources

Twenty-seven independent research studies in the Global Alzheimer's Association Interactive Network with data on nearly 58 000 participants.

Study selection

Non-Hispanic white individuals with clinical diagnostic and APOE genotype data.

Data extraction and synthesis

Homogeneous data sets were pooled in case-control analyses, and logistic regression models were used to compute risks.

Main out

SUBMITTER: Neu SC 

PROVIDER: S-EPMC5759346 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature