Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial: A case-cohort study.

ABSTRACT:

Background

The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events.

Methods

We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significa

SUBMITTER: Razquin C 

PROVIDER: S-EPMC5759348 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature