Effect of time to initiation of postoperative radiation therapy on survival in surgically managed head and neck cancer.

ABSTRACT:

Background

The objective of this study was to determine the effects of National Comprehensive Cancer Network (NCCN) guideline-adherent initiation of postoperative radiation therapy (PORT) and different time-to-PORT intervals on the overall survival (OS) of patients with head and neck squamous cell carcinoma (HNSCC).

Methods

The National Cancer Data Base was reviewed for the period of 2006-2014, and patients with HNSCC undergoing surgery and PORT were identified. Kaplan-Meier survival estimates, Cox regression analysis, and propensity score matching were used to determine the effects of initiating PORT within 6 weeks of surgery and different time-to-PORT intervals on survival.

Results

This study included 41,291 patients. After adjustments for covariates, starting PORT

SUBMITTER: Graboyes EM 

PROVIDER: S-EPMC5759768 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature