Immunotherapy: A New (and Old) Approach to Treatment of Soft Tissue and Bone Sarcomas.

ABSTRACT: Soft tissue and bone sarcomas are a rare and heterogeneous form of cancer. With standard of care treatment options including surgery, radiation, and chemotherapy, the long-term survival is still low for high-risk soft tissue sarcoma patients. New treatment strategies are needed. Immunotherapy offers a new potential treatment paradigm with great promise. Immunotherapy of soft tissue sarcomas dates back to Dr. Coley's first use of toxins in the late 1800s. A variety of strategies of immunotherapy have been tried in soft tissue and bone sarcomas, including various vaccines and cytokines, with limited success. Results of these early clinical trials with vaccines and cytokines were disappointing, but there are reasons to be optimistic. Recent advances, particularly with the use of adoptive T-ce

SUBMITTER: Nathenson MJ 

PROVIDER: S-EPMC5759816 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature