Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda.

ABSTRACT:

Background

Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, is being substituted in many settings by circulating antigen recognition-based diagnostics, usually the point-of-care circulating cathodic antigen test (CCA). The relationship between these diagnostics is poorly understood, particularly after treatment in both drug-efficacy studies and routine monitoring.

Results

We created a model of schistosome infections to better understand and quantify the relationship between these two egg- and adult worm antigen-based diagnosti

SUBMITTER: Prada JM 

PROVIDER: S-EPMC5759883 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature