Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients.

ABSTRACT:

Background

To provide further information on the clinical and pathological prognostic factors in triple-negative breast cancer (TNBC), for which limited and inconsistent data are available.

Methods

Pathological characteristics and clinical records of 841 TNBCs diagnosed between 1994 and 2015 in four major oncologic centers from Sardinia, Italy, were reviewed. Multivariate hazard ratios (HRs) for mortality and recurrence according to various clinicopathological factors were estimated using Cox proportional hazards models.

Results

After a mean follow-up of 4.3 years, 275 (33.3%) TNBC patients had a progression of the disease and 170 (20.2%) died. After allowance for study center, age at diagnosis, and various clinicopathological factors, all components of the TNM stagin

SUBMITTER: Urru SAM 

PROVIDER: S-EPMC5759886 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature