Proteomics reveals changes in hepatic proteins during chicken embryonic development: an alternative model to study human obesity.

ABSTRACT:

Background

Chicken embryos are widely used as a model for studies of obesity; however, no detailed information is available about the dynamic changes of proteins during the regulation of adipose biology and metabolism. Thus, the present study used an isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic approach to identify the changes in protein abundance at different stages of chicken embryonic development.

Results

In this study, the abundances of 293 hepatic proteins in 19-day old of chicken embryos compared with 14-day old and 160 hepatic proteins at hatching compared with 19-day old embryos were significantly changed. Pathway analysis showed that fatty acid degradation (upregulated ACAA2, CPT1A, and ACOX1), protein folding (upregulated PDIs, CALR3

SUBMITTER: Peng M 

PROVIDER: S-EPMC5759888 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature