Effect of Temperature on the Size Distribution, Shell Properties, and Stability of Definity®.

ABSTRACT: Physical characterization of an ultrasound contrast agent (UCA) aids in its safe and effective use in diagnostic and therapeutic applications. The goal of this study was to investigate the impact of temperature on the size distribution, shell properties, and stability of Definity®, a U.S. Food and Drug Administration-approved UCA used for left ventricular opacification. A Coulter counter was modified to enable particle size measurements at physiologic temperatures. The broadband acoustic attenuation spectrum and size distribution of Definity® were measured at room temperature (25 °C) and physiologic temperature (37 °C) and were used to estimate the viscoelastic shell properties of the agent at both temperatures. Attenuation and size distribution was measured over time to assess the effect

SUBMITTER: Shekhar H 

PROVIDER: S-EPMC5759968 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature