Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain.

ABSTRACT: Long-term alcohol use can result in lasting changes in brain function, ultimately leading to alcohol dependence. These functional alterations arise from dysregulation of complex gene networks, and growing evidence implicates microRNAs as key regulators of these networks. We examined time- and brain region-dependent changes in microRNA expression after chronic intermittent ethanol (CIE) exposure in C57BL/6J mice. Animals were sacrificed at 0, 8, and 120h following the last exposure to four weekly cycles of CIE vapor and we measured microRNA expression in prefrontal cortex (PFC), nucleus accumbens (NAC), and amygdala (AMY). The number of detected (395-419) and differentially expressed (DE, 42-47) microRNAs was similar within each brain region. However, the DE microRNAs were distinct among br

SUBMITTER: Osterndorff-Kahanek EA 

PROVIDER: S-EPMC5760035 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature