Host triacylglycerols shape the lipidome of intracellular trypanosomes and modulate their growth.

ABSTRACT: Intracellular infection and multi-organ colonization by the protozoan parasite, Trypanosoma cruzi, underlie the complex etiology of human Chagas disease. While T. cruzi can establish cytosolic residence in a broad range of mammalian cell types, the molecular mechanisms governing this process remain poorly understood. Despite the anticipated capacity for fatty acid synthesis in this parasite, recent observations suggest that intracellular T. cruzi amastigotes may rely on host fatty acid metabolism to support infection. To investigate this prediction, it was necessary to establish baseline lipidome information for the mammalian-infective stages of T. cruzi and their mammalian host cells. An unbiased, quantitative mass spectrometric analysis of lipid fractions was performed with the identific

SUBMITTER: Gazos-Lopes F 

PROVIDER: S-EPMC5760102 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature