The self-reference effect in dementia: Differential involvement of cortical midline structures in Alzheimer's disease and behavioural-variant frontotemporal dementia.

ABSTRACT: Encoding information in reference to the self enhances subsequent memory for the source of this information. In healthy adults, self-referential processing has been proposed to be mediated by the cortical midline structures (CMS), with functional differentiation between anterior-ventral, anterior-dorsal and posterior regions. While both Alzheimer's disease (AD) and behavioural-variant frontotemporal dementia (bvFTD) patients show source memory impairment, it remains unclear whether they show a typical memory advantage for self-referenced materials. We also sought to identify the neural correlates of this so-called 'self-reference effect' (SRE) in these patient groups. The SRE paradigm was tested in AD (n = 16) and bvFTD (n = 22) patients and age-matched healthy controls (n = 17). In this t

SUBMITTER: Wong S 

PROVIDER: S-EPMC5760181 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature