Affinity interactions drive post-implantation drug filling, even in the presence of bacterial biofilm.

ABSTRACT: Current post-operative standard of care for surgical procedures, including device implantations, dictates prophylactic antimicrobial therapy, but a percentage of patients still develop infections. Systemic antimicrobial therapy needed to treat such infections can lead to downstream tissue toxicities and generate drug-resistant bacteria. To overcome issues associated with systemic drug administration, a polymer incorporating specific drug affinity has been developed with the potential to be filled or refilled with antimicrobials, post-implantation, even in the presence of bacterial biofilm. This polymer can be used as an implant coating or stand-alone drug delivery device, and can be translated to a variety of applications, such as implanted or indwelling medical devices, and/or surgical si

SUBMITTER: Cyphert EL 

PROVIDER: S-EPMC5760245 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature