Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions.

ABSTRACT: Chronic wounds affect 12-15% of patients with diabetes and are associated with a drastic decrease in their quality of life. Here, we demonstrate that purified mature naive B220⁺ /CD19⁺ /IgM⁺ /IgD⁺ B cells improve healing of acute and diabetic murine wounds after a single topical application. B cell treatment significantly accelerated acute wound closure by 2-3 days in wild-type mice and 5-6 days in obese diabetic mice. The treatment led to full closure in 43% of chronic diabetic wounds, as compared to only 5% in saline-treated controls. Applying equivalent numbers of T cells or disrupted B cells failed to reproduce these effects, indicating that live B cells mediated pro-healing responses. Topically applied B cell treatment was associated with si

SUBMITTER: Sirbulescu RF 

PROVIDER: S-EPMC5760362 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature