MPGES1-Dependent Prostaglandin E₂ (PGE₂) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE₂ Production.

ABSTRACT: The integration of inflammatory signals is paramount in controlling the intensity and duration of immune responses. Eicosanoids, particularly PGE₂, are critical molecules in the initiation and resolution of inflammation and in the transition from innate to acquired immune responses. Microsomal PGE synthase 1 (mPGES1) is an integral membrane enzyme whose regulated expression controls PGE₂ levels and is highly expressed at sites of inflammation. PGE₂ is also associated with modulation of autoimmunity through altering the IL-23/IL-17 axis and regulatory T cell (Treg) development. During a type II collagen-CFA immunization response, lack of mPGES1 impaired the numbers of CD4⁺ regulatory (Treg) and Th17 cells in the draining lymph nodes. Ag-experience

SUBMITTER: Maseda D 

PROVIDER: S-EPMC5760456 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature