Influence of Baseline Diastolic Blood Pressure on Effects of Intensive Compared With Standard Blood Pressure Control.

ABSTRACT:

Background

In individuals with a low diastolic blood pressure (DBP), the potential benefits or risks of intensive systolic blood pressure (SBP) lowering are unclear.

Methods

SPRINT (Systolic Blood Pressure Intervention Trial) was a randomized controlled trial that compared the effects of intensive (target <120 mm Hg) and standard (target <140 mm Hg) SBP control in 9361 older adults with high blood pressure at increased risk of cardiovascular disease. The primary outcome was a composite of cardiovascular disease events. All-cause death and incident chronic kidney disease were secondary outcomes. This post hoc analysis examined whether the effects of the SBP intervention differed by baseline DBP.

Results

Mean baseline SBP and DBP were 139.7±15.6 and 78.1±11.9 mm Hg, res

SUBMITTER: Beddhu S 

PROVIDER: S-EPMC5760457 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature