Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting.

ABSTRACT:

Purpose

To investigate the utility of an advanced magnetic resonance spectroscopy (MRS) protocol in the clinical setting, and to compare the localization accuracy, spectral quality, and quantification repeatability between this advanced and the conventional vendor-provided MRS protocol on a clinical 3T platform.

Methods

Proton spectra were measured from the posterior cingulate cortices in 30 healthy elderly subjects by clinical MR technologists using a vendor-provided (point resolved spectroscopy with advanced 3D gradient-echo B₀ shimming) and an advanced (semi-LASER with FAST(EST)MAP shimming) protocol, in random order. Spectra were quantified with LCModel using standard pipelines for the clinical and research settings, respectively.

Results

The advanced p

SUBMITTER: Deelchand DK 

PROVIDER: S-EPMC5760483 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature