Regulation of Innate Lymphoid Cells by Aryl Hydrocarbon Receptor.

ABSTRACT: With striking similarity to their adaptive T helper cell counterparts, innate lymphoid cells (ILCs) represent an emerging family of cell types that express signature transcription factors, including T-bet⁺ Eomes⁺ natural killer cells, T-bet⁺ Eomes^- group 1 ILCs, GATA3⁺ group 2 ILCs, RORγt⁺ group 3 ILCs, and newly identified Id3⁺ regulatory ILC. ILCs are abundantly present in barrier tissues of the host (e.g., the lung, gut, and skin) at the interface of host-environment interactions. Active research has been conducted to elucidate molecular mechanisms underlying the development and function of ILCs. The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor, best known to mediate the effects of

SUBMITTER: Li S 

PROVIDER: S-EPMC5760495 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature