Inflammatory Proteomic Network Analysis of Statin-treated and Lipopolysaccharide-activated Macrophages.

ABSTRACT: A significant component of immune biology research is the investigation of protein encoding genes that play central roles in contributing inflammatory response. A gel-free quantitative bottom-up proteomics study was performed on immune cell macrophages after the combined treatment of lipopolysaccharide (LPS) and statin drugs using mass spectrometry and a detailed bioinformatics analyses were conducted. Systematic bioinformatics analysis was applied for discovering novel relationships among proteins and effects of statin and lipopolysaccharide in macrophage cells. Based on gene ontology, majority of protein encoding genes was involved in metabolic and cellular processes and are actively associated with binding, structural molecular, and catalytic activity. Notably, proteomic data analyzed b

SUBMITTER: Kamal AHM 

PROVIDER: S-EPMC5760528 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature