Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice.

ABSTRACT: Excessive exposure to glucocorticoids causes osteoporosis in children and adults. Occlusal disharmony is known to induce an increase in serum corticosteroid levels in murine models, but the influence of occlusal disharmony-induced stress on the bone mass during the growth period has not yet been clarified. The purpose of this study was to investigate whether occlusal disharmony-induced stress decreases bone mass. Five-week-old C57BL/6J male mice were used. A 0.5-mm increase in the vertical height of occlusion was used to induce occlusal disharmony for a period of 7 days. Serum corticosterone levels were significantly higher on post-induction day 7, with radiological evidence of osteopenia of the third lumbar vertebra and long bones of the hind limbs. Osteopenia was associated with a reduct

SUBMITTER: Shimizu Y 

PROVIDER: S-EPMC5760568 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature