Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum.

ABSTRACT:

Background

Antigen-detecting rapid diagnostic tests (RDTs) have been recommended by the World Health Organization for use in remote areas to improve malaria case management. Lactate dehydrogenase (LDH) of Plasmodium falciparum is one of the main parasite antigens employed by various commercial RDTs. It has been hypothesized that the poor detection of LDH-based RDTs is attributed in part to the sequence diversity of the gene. To test this, the present study aimed to investigate the genetic diversity of the P. falciparum ldh gene in Thailand and to construct the map of LDH sequence diversity in P. falciparum populations worldwide.

Methods

The ldh gene was sequenced for 50 P. falciparum isolates in Thailand and compared with hundreds of sequences from P. falciparum populations

SUBMITTER: Simpalipan P 

PROVIDER: S-EPMC5761093 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature