Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65.

ABSTRACT:

Background

Cerebral malaria and severe anaemia are the most common deadly complications of malaria, and are often associated, both in paediatric and adult patients, with hepatopathy, whose pathogenesis is not well characterized, and sometimes also with acute respiratory distress syndrome (ARDS). Here, two species of murine malaria, the lethal Plasmodium berghei strain NK65 and self-healing Plasmodium chabaudi strain AS which differ in their ability to cause hepatopathy and/or ARDS were used to investigate the lipid alterations, oxidative damage and host immune response during the infection in relation to parasite load and accumulation of parasite products, such as haemozoin.

Methods

Plasma and livers of C57BL/6J mice injected with PbNK65 or PcAS infected erythrocytes were co

SUBMITTER: Scaccabarozzi D 

PROVIDER: S-EPMC5761140 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature