Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study.

ABSTRACT:

Background

Glucocorticoids are associated with increased fracture risk and are the mainstay of treatment in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). However, fracture risk in these conditions has not been previously quantified. The aim of this study was to quantify the risk of fracture among patients with PMR and GCA.

Methods

A retrospective cohort study was conducted using primary care records from the UK-based Clinical Practice Research Datalink. Individuals aged 40 years and over, with incident diagnoses of PMR or GCA were separately identified from 1990-2004 and followed up until 2015. For each exposed individual, four age-, sex- and practice-matched controls were randomly selected. Incidence rates of fracture per 10,000 person-years were calculated f

SUBMITTER: Paskins Z 

PROVIDER: S-EPMC5761155 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature