Progesterone Suppression of Luteinizing Hormone Pulse Frequency in Adolescent Girls With Hyperandrogenism: Effects of Metformin.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS) and adolescent hyperandrogenism (HA) are characterized by rapid luteinizing hormone (LH) pulse frequency. This partly reflects impaired gonadotropin-releasing hormone pulse generator (hypothalamic) sensitivity to progesterone (P4) negative feedback. We assessed whether metformin may improve P4 sensitivity in adolescent HA, for which it is prescribed widely.

Objective

To test the hypothesis that metformin improves hypothalamic P4 sensitivity in adolescent HA.

Design

Nonrandomized, interventional trial.

Setting

Academic clinical research unit.

Participants

Ten adolescent girls with HA.

Intervention

The girls underwent LH sampling every 10 minutes for 11 hours, at study baseline and after 7 days of oral P4 and

SUBMITTER: Lundgren JA 

PROVIDER: S-EPMC5761484 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature