The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis.

ABSTRACT:

Background

Extensive resections in low-grade glioma (LGG) are associated with improved overall survival (OS). However, World Health Organization (WHO) classification of gliomas has been completely revised and is now predominantly based on molecular criteria. This requires reevaluation of the impact of surgery in molecularly defined LGG subtypes.

Methods

We included 228 adults who underwent surgery since 2003 for a supratentorial LGG. Pre- and postoperative tumor volumes were assessed with semiautomatic software on T2-weighted images. Targeted next-generation sequencing was used to classify samples according to current WHO classification. Impact of postoperative volume on OS, corrected for molecular profile, was assessed using a Cox proportional hazards model.

Results

SUBMITTER: Wijnenga MMJ 

PROVIDER: S-EPMC5761503 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature