Differences in adaptive dynamics determine the success of virus variants that propagate together.

ABSTRACT: Virus fitness is a complex parameter that results from the interaction of virus-specific characters (e.g. intracellular growth rate, adsorption rate, virion extracellular stability, and tolerance to mutations) with others that depend on the underlying fitness landscape and the internal structure of the whole population. Individual mutants usually have lower fitness values than the complex population from which they come from. When they are propagated and allowed to attain large population sizes for a sufficiently long time, they approach mutation-selection equilibrium with the concomitant fitness gains. The optimization process follows dynamics that vary among viruses, likely due to differences in any of the parameters that determine fitness values. As a consequence, when different mutants

SUBMITTER: Arribas M 

PROVIDER: S-EPMC5761584 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature