Avian influenza H5N1 vaccination efficacy in Egyptian backyard poultry.

ABSTRACT: Raising backyard poultry under low biosecurity conditions is a common practice in Egypt. While vaccination is routinely applied in Egypt in commercial settings to curb the spread of avian influenza viruses, it remains less commonly used in backyard settings. We assessed the immunogenicity and protective efficacy of a H5N1 vaccine based on a contemporary Egyptian clade 2.2.1.2 virus among turkeys, ducks, geese, and chickens raised together in a backyard setting. Results showed that this vaccine elicits an immune response in all tested species reaching up to a hemagglutination inhibition titer of 10 log₂ after a booster dose. However, this response varied between species. When challenged, vaccinated birds survived and shed less virus in comparison with unvaccinated birds. However,

SUBMITTER: Kandeil A 

PROVIDER: S-EPMC5761674 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature