The effects of remote ischaemic preconditioning on coronary artery function in patients with stable coronary artery disease.

ABSTRACT:

Background

Remote ischaemic preconditioning (RIPC) is a cardioprotective intervention invoking intermittent periods of ischaemia in a tissue or organ remote from the heart. The mechanisms of this effect are incompletely understood. We hypothesised that RIPC might enhance coronary vasodilatation by an endothelium-dependent mechanism.

Methods

We performed a prospective, randomised, sham-controlled, blinded clinical trial. Patients with stable coronary artery disease (CAD) undergoing elective invasive management were prospectively enrolled, and randomised to RIPC or sham (1:1) prior to angiography. Endothelial-dependent vasodilator function was assessed in a non-target coronary artery with intracoronary infusion of incremental acetylcholine doses (10^-6, 10^-5

SUBMITTER: Corcoran D 

PROVIDER: S-EPMC5761717 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature