FOXA1 hypermethylation: link between parity and ER-negative breast cancer in African American women?

ABSTRACT:

Background

Reproductive factors, particularly parity, have differential effects on breast cancer risk according to estrogen receptor (ER) status, especially among African American (AA) women. One mechanism could be through DNA methylation, leading to altered expression levels of genes important in cell fate decisions.

Methods

Using the Illumina 450K BeadChip, we compared DNA methylation levels in paraffin-archived tumor samples from 383 AA and 350 European American (EA) women in the Women's Circle of Health Study (WCHS). We combined 450K profiles with RNA-seq data and prioritized genes based on differential methylation by race, correlation between methylation and gene expression, and biological function. We measured tumor protein expression and assessed its relationship to D

SUBMITTER: Espinal AC 

PROVIDER: S-EPMC5761729 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature