PSCA rs1045531 Polymorphism and the Risk of Prostate Cancer in a Chinese Population Undergoing Prostate Biopsy.

ABSTRACT:

Background and purpose

This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy.

Materials and methods

DNA from 416 patients undergoing prostate biopsy was typed for the prostate stem cell antigen rs1045531 single-nucleotide polymorphism. The frequency of the rs1045531 polymorphism in patients with prostate cancer and in patients with benign prostatic hyperplasia was compared. Associations between the polymorphism and the risk of prostate cancer, prostate special antigen, Gleason score, and clinical stage were analyzed.

Results

Statistically significant differences in the distribution of the rs1045531 genotypes and alleles were found between prostate ca

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5762085 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature