Role of OATP transporters in steroid uptake by prostate cancer cells in vivo.

ABSTRACT:

Background

Epidemiologic and in vitro studies suggest that SLCO-encoded organic anion transporting polypeptide (OATP) transporters influence the response of prostate cancer (PCa) to androgen deprivation by altering intratumor androgens. We have previously shown that castration-resistant metastases express multiple SLCO transporters at significantly higher levels than primary PCa, suggesting that OATP-mediated steroid transport is biologically relevant in advanced disease. However, whether OATP-mediated steroid transport can actually modify prostate tumor androgen levels in vivo has never been demonstrated.

Methods

We sought to determine whether OATP-mediated steroid transport can measurably alter PCa androgen levels in vivo. We evaluated the uptake of dehydroepiandrosterone

SUBMITTER: Green SM 

PROVIDER: S-EPMC5762123 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature