Gene expression profiling and construction of a putative gene regulatory network of bladder cancer tumor-initiating cells.

ABSTRACT: Human bladder cancer tumors have been shown to contain a subpopulation of cells with stem-like characteristics that may trigger tumor growth, recurrence, and metastasis. These cells, known as tumor-initiating cells (TICs), would be effective diagnostic tools and valuable therapeutic targets. Here, we report the isolation of TICs from seven bladder cancer cell lines and show that TICs from different sources vary on their ability to form tumorspheres in vitro and generate xenografts in vivo, which suggest they are remarkably heterogeneous. We used the Affymetrix PrimeView™ Human Gene Expression Array to analyze gene expression profiles of bladder TICs, which may help understand their tumorigenic capacities and develop novel treatments specifically targeted toward these cells. W

SUBMITTER: Xin Z 

PROVIDER: S-EPMC5762320 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature